Iakovos Toumazis is an Assistant Professor at the Department of Health Services Research, Division of Cancer Prevention and Population Sciences at The University of Texas MD Anderson Cancer Center. He completed his Bachelor of Science (B.S.) in Mathematics with a major in Probability and Statistics at University of Patras, Greece in 2009. He completed his Master and Doctoral degrees in Operations Research at the Industrial & Systems Engineering department of the State University of New York at Buffalo. Part of his doctoral dissertation received the Best Graduate Student Paper award from the Society for Health Systems of the Institute of Industrial & Systems Engineers (2015). His research received funding from the National Institutes of Health (NIH) National Cancer Institute (NCI), the Duncan Family Institute for Cancer Prevention and Risk Assessment Seed-Funding Research Program, the National Association for Proton Therapy (NAPT), and the Break Through Cancer. His research interests include sequential decision making under uncertainty, applications of Operations Research in healthcare, simulation systems, robust optimization, and cost-effectiveness analyses of healthcare interventions.

Department of Health Services Research
Division of Cancer Prevention and Population Sciences
The University of Texas MD Anderson Cancer Center

Biomedical Data Science and Radiology, Stanford School of Medicine

University at Buffalo, SUNY, Amherst, NY

Dissertation: "Dynamic Chemotherapy Scheduling for Metastatic Colorectal Cancer Patients: Assessments and Improvements"

University at Buffalo, SUNY, Amherst, NY

Thesis: "Time-Dependent Conditional Value-at-Risk Minimization Algorithm for Hazardous Materials Routing"

University of Patras, Greece

Thesis: "Dynamic Programming"

 Journal Articles

Toumazis I, Cao P, de Nijs K, Bastani M, Munshi V, Hemmati M, Ten Haaf K, Jeon J, Tammemägi M, Gazelle GS, Feuer EJ, Kong CY, Meza R, de Koning HJ, Plevritis SK, Han SS. Risk Model-Based Lung Cancer Screening : A Cost-Effectiveness Analysis. Ann Intern Med. 2023 Feb 7. doi: 10.7326/M22-2216. Epub ahead of print. PMID: 36745885.

Maki KG, Talluri R, Toumazis I, Shete S, Volk RJ. Impact of U.S. Preventive Services Task Force lung cancer screening update on drivers of disparities in screening eligibility. Cancer Med. 2023 Feb;12(4):4647-4654. doi: 10.1002/cam4.5066. Epub 2022 Jul 24. PMID: 35871312; PMCID: PMC9972155.

Toumazis I, de Nijs K, Cao P, Bastani M, Munshi V, Ten Haaf K, Jeon J, Gazelle GS, Feuer EJ, de Koning HJ, Meza R, Kong CY, Han SS, Plevritis SK. Cost-effectiveness Evaluation of the 2021 US Preventive Services Task Force Recommendation for Lung Cancer Screening. JAMA Oncol. 2021 Oct 21. doi: 10.1001/jamaoncol.2021.4942. Epub ahead of print. PMID: 34673885.

Toumazis I, Erdogan SA, Bastani M, Leung A, Plevritis SK. A Cost-Effectiveness Analysis of Lung Cancer Screening With Low-Dose Computed Tomography and a Diagnostic Biomarker, JNCI Cancer Spectrum, Volume 5, Issue 6, December 2021, pkab081, doi: 10.1093/jncics/pkab081. Epub ahead of print.

Bastani M, Toumazis I, Hedou' J, Leung A, Plevritis SK. "Evaluation of Alternative Diagnostic Follow-up Intervals for Lung Reporting and Data System Criteria on the Effectiveness of Lung Cancer Screening," J Am Coll Radiol, 2021 Aug 19:S1546-1440(21)00642-6. doi: 10.1016/j.jacr.2021.08.001. Epub ahead of print. PMID: 34419477.

Toumazis I, Alagoz O, Leung A, Plevritis SK. "A risk-based framework for assessing real-time lung cancer screening eligibility that incorporates life expectancy and past screening findings," Cancer, 2021; Aug 12. doi: 10.1002/cncr.33835. Epub ahead of print. PMID: 34383299.

Meza R., Jeon J., Toumazis I., ten Haaf K., Cao P., Bastani M., Han S.S., Blom E.F., Jonas D.E., Feuer E.J., Plevritis S.K., de Koning H.J., Kong C.Y., "Evaluation of the Benefits and Harms of Lung Cancer Screening With Low-Dose Computed Tomography - Modeling Study for the US Preventive Services Task Force," JAMA, 2021;325(10):988-997, doi:10.1001/jama.2021.1077

Harrison R.F., Cantor S.B., Sun C.C., Villanueva M., Westin S.N., Fleming N.D., Toumazis I., Sood A.K., Lu K.H., Meyer L.A., "Cost-effectiveness of laparoscopic disease assessment in patients with newly diagnosed advanced ovarian cancer," Gynecologic Oncology, 2021.

Han S.S., Chow E., ten Haaf K., Toumazis I., Cao P., Bastani M., Tammemagi M., Jeon J., Feuer E., Meza R., Plevritis S., "Disparities of national lung cancer screening guidelines in the U.S. population," JNCI, 2020, 112 (11): 1136–1142.

ten Haaf K., Bastani M., Cao P., Jeon J., Toumazis I., Han S.S., Plevritis S.K., Blom E.F., Kong C.Y., Tammemägi M.C., Feuer E.J., Meza R., de Koning H.J., "A comparative modeling analysis of risk-based lung cancer screening strategies," JNCI, 2020, 112 (5): 466–479.

Criss S.D., Cao P., Bastani M., ten Haaf K., Chen Y., Sheehan D.F., Blom E.F., Toumazis I., Jeon J., de Koning H.J., Plevritis S.K., Meza R., Kong C.Y., "Cost-Effectiveness Analysis of Lung Cancer Screening in the United States: A Comparative Modeling Study," Ann Intern Med., 2019, 171:796-804.

Toumazis I., Tsai E.B., Erdogan S.A., Han, S.S., Wan, W., Leung, A., Plevritis, S.K., "Cost-Effectiveness Analysis of Lung Cancer Screening Accounting for the Effect of Indeterminate Findings", JNCI Cancer Spectrum, 2019, 3 (3):pkz035.

Tammemägi M.C., ten Haaf K., Toumazis I., Kong C.Y., Han S.S., Jeon J., Commins J., Riley T., Meza R., "Development and validation of a multivariable lung cancer risk prediction model that includes low-dose computed tomography screening results: A secondary analysis of data from the National Lung Screening Trial", JAMA Network Open, 2019, 2 (3):e190204

Toumazis I., Kurt M., Toumazi A., Karacosta L.G., Kwon C., "Comparative Effectiveness of Up-to-Three Lines of Chemotherapy Treatment Plans for Metastatic Colorectal Cancer", MDM Policy & Practice, 2017, 2 (2), 2381468317729650

Han S.S., Erdogan S.A, Toumazis I., Leung A., Plevritis S.K., "Evaluating the impact of varied compliance to lung cancer screening recommendations using a microsimulation model", Cancer Causes & Control, 2017, 28 (9): 947-958

Toumazis I., Kwon C., "Worst-case conditional value-at-risk minimization for hazardous materials transportation", Transportation Science, 2015, 50 (4): 1174-1187

Toumazis I., Kwon C., "Routing hazardous materials on time-dependent networks using conditional value-at-risk", Transportation Research Part C: Emerging Technologies, 2013, 37: 73-92

 Book Chapters

Toumazis I., Kwon C., and Batta R. (2013), "Value-at-Risk and Conditional Value-at-Risk Minimization for Hazardous Materials Routing", in Handbook of OR/MS Models in Hazardous Materials Transportation (Eds.:R. Batta and C. Kwon), Springer

 Review Articles

Toumazis I., Bastani M., Han S.S., Plevritis S.K., "Risk-based lung cancer screening: A systematic review," Lung Cancer, Vol 147, pp. 154-186, 2020, doi:10.1016/j.lungcan.2020.07.007

Toumazis I., "Personalized Lung Cancer Screening: The ENGAGE Framework", MD Anderson EDRN LUNG CVC Meeting, Feb 23-24, 2023 Houston, TX

Toumazis I., "Changing the paradigm of lung cancer prevention using mathematical models," CyBioS Mini Symposium 2023 CancerNow: From Benchside to Clinical Applications, The Cyprus Biological Society, Cyprus, January 5, 2023

Toumazis I., "Informing Lung Cancer Screening Policy Using Decision-Analytic Models," Cancer Prevention and Control Grand Rounds, The University of Texas MD Anderson Cancer Center, Houston, TX, June 3, 2022

Toumazis I., "Personalizing Lung Cancer Screening Using a Decision-Analytic Model: Insights from the ENGAGE Framework," ClubMeth Seminar Series, Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands, November 8, 2021

Toumazis I., "Personalizing Lung Cancer Screening Using a Decision-Analytic Model: Insights from the ENGAGE Framework," UT MD Anderson Data Science and Modeling Forum, April 2021

Hemmati M., Toumazis I., Schaefer A.J., "Personalized optimal lung cancer screening schedules: Study of implementable strategies via enforcing policy structure," 2021 INFORMS Annual Meeting, Anaheim, CA

Toumazis I., "Accounting for Racial Differences in Optimizing Lung Cancer Screening Schedules," 2021 INFORMS Healthcare Meeting, Virtual Meeting

Toumazis I., "Operations Research and Cancer Care: Could this be the answer for better outcomes?," Health Services Research Seminar, The University of Texas MD Anderson Cancer Center, Houston, TX, December 2020

Toumazis I., "A New Paradigm in Lung Cancer Screening: Screening for Individuals not Populations," Roswell Park Comprehensive Cancer Center, Buffalo, NY, August, 2019

Toumazis I., "The Future of Lung Cancer Screening: Is Personalized Screening Necessary and Feasible?," Division of Cancer Control \& Population Sciences, National Cancer Institute (NCI), Rockville, MD, July 2019

Toumazis I., "Personalized Lung Cancer Screening: The Individualized Lung Screening Scheduler (ILungSS)," 2019 CISNET Mid-Year Meeting, Junior Investigators Meeting, Seattle, WA, May 2019

Toumazis I., "Lung Cancer Screening: Is Individualized Screening a Feasible Solution to Existing Problems?," The University of Texas MD Anderson Cancer Center, Houston, TX, March 2019

Toumazis I., Alagoz O., Leung A., Plevritis S.K., "Individualized Risk-Based Lung Cancer Screening Incorporating Past Screening Findings and Changes in Smoking Behaviors," 2019 World Conference on Lung Cancer, Barcelona, Spain

Han S.S., Chow E., ten Haaf K., Toumazis I., Bastani M., Tammemagi M.C., Jeon J., Feuer E., Meza R., Plevritis S.K., "Disparities and National Lung Cancer Screening Guidelines in the U.S. Population," 2019 World Conference on Lung Cancer, Barcelona, Spain

Toumazis I., Alagoz O., Leung A., Plevritis S.K., "Personalized lung cancer screening strategies using a partially observable Markov decision process", 2019 INFORMS Healthcare, Cambridge, MA, July 27–29, 2019

Bastani M., Toumazis I., Leung A.,Plevritis S.K., "Evaluation of Alternative Subsequent Screening for LungRADS Criteria on the Effectiveness of Lung Cancer Screening", 2019 INFORMS Healthcare, Cambridge, MA, July 27–29, 2019

Toumazis I., "Personalizing Lung Cancer Screening Using a Partially Observable Markov Decision Process," 2018 Stanford Intelligent Systems Lab Meeting, Stanford, CA, August 2018

Toumazis I., Alagoz O., Leung A., Plevritis S.K., "Personalized lung cancer screening strategies using a partially observable Markov decision process", 2018 INFORMS Annual Meeting, Phoenix, AZ, November 4–7, 2018

Toumazis I., Tsai E.B., Erdogan A., Han S., Leung A., Plevritis S.K., "The effect of indeterminate findings on the cost-effectiveness of lung cancer screening", 2018 INFORMS Annual Meeting, Phoenix, AZ, November 4–7, 2018

Bastani M., Plevritis S.K., Toumazis I., Leung A., "Evaluation of alternative diagnostic test intervals and thresholds for Lung-RADS criteria on the effectiveness of lung cancer screening", 2018 INFORMS Annual Meeting, Phoenix, AZ, November 4–7, 2018

Toumazis I., Tsai E., Erdogan A., Han S.S., Wan W., Leung A., Plevritis S.K., "Impact Of False-Positives On The Cost-effectiveness of Lung Cancer Screening" 2017 INFORMS Healthcare Conference, Rotterdam, Netherlands, July 26–28, 2017

Toumazis I., Erdogan A., Plevritis S.K., "Evaluating The Impact Of Diagnostic Biomarkers On The Cost-effective Efficiency Frontier Of Alternative Lung Cancer Screening Strategies" 2016 INFORMS International Conference, Hawaii, HA, June 12–15, 2016

Toumazis I., Kurt M., Toumazi A., Karacosta L.G., Kwon C., "Personalized Treatment Decisions For Metastatic Colorectal Cancer Patients", 2016 INFORMS International Conference, Hawaii, HA, June 12–15, 2016

Toumazis I., Kurt M., Toumazi A., Karacosta L.G., Kwon C., Goldstein D., "Sequencing Chemotherapy Agents for Metastatic Colorectal Cancer Patients", INFORMS Annual Meeting 2015, Philadelphia, PA, November 1–4, 2015

Toumazis I., Kurt M., Toumazi A., Karacosta L.G., Kwon C., Goldstein D., "Assessing the role of sequencing up to three lines of chemotherapy in metastatic colorectal cancer treatment: A cost effectiveness analysis" The 37th Annual Meeting of the Society of Medical Decision Making, St. Louis, MO, October 18–21, 2015

Toumazis I., Karacosta L.G., Toumazi A., Kwon C., Kurt M., "Optimization of palliative chemotherapy scheduling for metastatic colorectal cancer patients", IIE Annual Conference & Expo 2015, Nashville, TN, May 30-June 2, 2015

Toumazis I., Karacosta L.G., Toumazi A., Kwon C., Kurt M., "Optimization of palliative chemotherapy scheduling for metastatic colorectal cancer patients" (Winner of the 2015 Society for Health Systems Graduate Student Paper Competition), Healthcare Systems Process Improvement Conference 2015, Orlando, FL, February 18-20, 2015

Toumazis I., Denton B., Kurt M., Osman O., Shah N., “Eliciting Cholesterol Management Guidelines' Valuation of Future Life”, INFORMS Annual Meeting 2014, San Francisco, CA, November 9–12, 2014

Toumazis I., Osman O., Kurt M., Denton B., “Eliciting Lipid Management Guidelines' Valuation of Future Life”, The 36th Annual Meeting of the Society of Medical Decision Making, Miami, FL, October 18–22, 2014

Toumazis I., Kwon C., “Advanced Risk Measures Applied in Hazardous Materials Routing”, INFORMS Annual Meeting 2013, Minneapolis, MN, October 6–9, 2013

Toumazis I., Kwon C., “Conditional Value-at-risk for Hazardous Materials Transportation on Time- dependent Networks”, INFORMS Annual Meeting 2012, Phoenix, AZ, October 14–17, 2012

Toumazis I., Kwon C., “Conditional Value-at-risk for Hazardous Materials Transportation on Time- dependent Networks”, CORS - SCRO 2012, Niagara Falls, ON, Canada, June 11–13, 2012

Toumazis I., Kwon C., “Conditional Value-at-risk for Hazardous Materials Transportation on Time-dependent Networks”, IIE Annual Meeting 2012, Orlando, FL, May 19–23, 2012

Kwon C., Toumazis I., Lee T., “Worst Case Conditional Value-at-Risk Minimization in Hazardous Materials Transportation”, INFORMS Annual Meeting 2011, Charlotte, NC, Nov 13–16, 2011

Department of Industrial & Systems Engineering, University at Buffalo, SUNY, Amherst, NY

EAS 305: Applied Probability & Statistics Inference (Summer 2015 - Enrollment: 18)

IE 320: Engineering Economy (Summer 2013 - Enrollment: 28)

Department of Industrial & Systems Engineering, University at Buffalo, SUNY, Amherst, NY

IE 507: Design of Experiments (Graduate level)

IE 514: Revenue Management (Graduate level)

IE 572: Linear Programming (Graduate level)

IE 504: Facility Design (Graduate level)

EAS 305: Applied Probability & Statistics Inference (Undergraduate level)

ELC Private Institute, Limassol, Cyprus

Responsible for the Mathematics Department

Taught all high school levels

(m-PI) Volk R.,Toumazis I., Godoy M., "Multicomponent Interventions to Improve Uptake and Adherence to Lung Cancer Screening (RP230213)", Cancer Prevention and Research Institute of Texas (CPRIT) , 3/1/2023 - 2/28/2028

(PI) Toumazis I., "Optimizing Personalized Screening and Diagnostic Decisions for Lung Cancer Based on Dynamic Risk Assessment and Life Expectancy (R37CA271187)", National Institutes of Health (NIH)/National Cancer Institute (NCI), 6/15/2022 - 5/31/2027

(PI) Toumazis I., "Development of a risk prediction and natural history models for ovarian cancer", Duncan Family Institute for Cancer Prevention and Risk Assessment Seed-Funding Research Program, 3/1/2022 - 2/28/2024

(Co-Investigator) Toumazis I., "Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions", National Institutes of Health, 9/1/2020 - 8/31/2025

(PI) Toumazis I., "Personalized, Dynamic Risk-based Lung Cancer Screening", National Institutes of Health, 7/1/2017 - 6/30/2019

(Consultant) Toumazis I., "Administrative Supplement to Controlling Esophageal Cancer: A Collaborative Modeling Approach", National Institutes of Health, 9/1/2019 - 8/31/2020

Best Poster Award, 2018 Integrative Biomedical Imagine Informatics at Stanford (IBIIS) Annual Retreat, Stanford University


Participated to the 2015 IIE Doctoral Colloquium


Winner of the Society for Health Systems 2015 Best Graduate Student Paper
Title: "Scheduling palliative chemotherapy treatment for metastatic stage colorectal cancer patients"

Full tuition assistantship, Department of Industrial & Systems Engineering, University at Buffalo, SUNY

University Transportation Research Center (UTRC) Travel Award, May 2012

European Journal of Operational Research (EJOR)





Transportation Research Part D: Transport and Environment

Annals of Mathematics & Artificial Intelligence

IIE Transactions on Healthcare Systems Engineering

Omega

Institute for Operations Research and the Management Sciences (INFORMS), Member

OmegaRho International Honor Society for Operations Research and Management Science, Member

Institute of Industrial and Systems Engineers (IISE), Member

Society for Medical Decision Making (SMDM), Member

International Association for the Study of Lung Cancer (IASLC), Member

Society for Health Systems (SHS), Member

CPLEX Optimizer

Matlab

Julia

R

LaTex

MS Office

GCE in Pure Mathematics (A’ Level)

GCE in Pure Mathematics (O’ Level)

GCE in Statistics (A’ Level)

GCE in Physics (O’ Level)

GCE in English Language (O’ Level)

Modern Greek (O’ Level)

Permanent Resident of United States